Resident Evil: Afterlife is a 2010 3D science-fiction action film written and directed by Paul W. S. Anderson, and starring Milla Jovovich, Ali Larter, Kim Coates, Shawn Roberts, Spencer Locke, Boris Kodjoe, and Wentworth Miller. It is the fourth installment in a series of film adaptations based loosely on Capcom's survival horror video game series Resident Evil. It is also the first film in the series to be released in 3D. In the film Alice searches for and rescues remaining survivors in Los Angeles of the T-virus outbreak, who team up against Albert Wesker, the head of the Umbrella Corporation.

In May 2005, producers mentioned the possibility of following Resident Evil: Extinction with a sequel titled Afterlife. Extinction was released in 2007 and was a box office success prompting Afterlife to begin development in June 2008, with the script being written by Anderson that December. Elements from the video game Resident Evil 5 were incorporated into the film.

Chris Redfield, a primary character from the video games was featured for the first time in the film franchise. Other characters from the games and films who return are: Claire Redfield, Albert Wesker, and Jill Valentine. Filming took place in Toronto from September to December 2009 using James Cameron's 3D Fusion Camera System. The film was released in 3D and IMAX 3D theaters on September 10, 2010.